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T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells

Date

Authors

Herlands, Robin A.

Christensen, Sean R.

Sweet, Rebecca

Hershberg, Uri

Shlomchik, M J

Publisher

Cell Press

Abstract

On the lupus-prone MRL-lpr/lpr (MRL-lpr) background, AM14 rheumatoid factor (RF) B cells are activated, differentiate into plasmablasts, and undergo somatic hypermutation outside of follicles. Using multiple strategies to impair T cells, we found that su

Keywords

Keywords: autoantibody; immunoglobulin G; ligand; myeloid differentiation factor 88; toll like receptor; toll like receptor 7; toll like receptor 9; animal experiment; article; B lymphocyte; B lymphocyte activation; cell differentiation; cell expansion; cell prolif CELLIMMUNO; MOLIMMUNO

URI

http://hdl.handle.net/1885/49985

Collections

ANU Research Publications

Source

Immunity

Type

Journal article

DOI

10.1016/j.immuni.2008.06.009

Restricted until

2037-12-31

Downloads

File

Description

01_Herlands_T_Cell-Independent_and_2008.pdf (1.71 MB)