Epstein-Barr virus genotypes and strains in central nervous system demyelinating disease and Epstein-Barr virus-related illnesses in Australia
dc.contributor.author | Lay, Meav-Lang | en_AU |
dc.contributor.author | Toi, Cheryl | en_AU |
dc.contributor.author | Ratnamohan, Mala | en_AU |
dc.contributor.author | Ponsonby, Anne-Louise | en_AU |
dc.contributor.author | Dwyer, Dominic E | en_AU |
dc.contributor.author | Ausimmune Investigator Group (AIG) | en_AU |
dc.contributor.author | Lucas, Robyn | en_AU |
dc.date.accessioned | 2015-12-10T23:13:56Z | |
dc.date.available | 2015-12-10T23:13:56Z | |
dc.date.issued | 2012 | |
dc.date.updated | 2016-02-24T09:46:18Z | |
dc.description.abstract | Objectives: To identify Epstein-Barr virus (EBV) genotypes and strains in samples from individuals with and without a first diagnosis of central nervous system (CNS) demyelinating disease (a possible precursor to multiple sclerosis) and patients with EBV-associated diseases in Australia. Methods: Samples from 55 EBV DNA and serology positive subjects including individuals with (n = 17) and without (n = 21) a first clinical diagnosis of CNS demyelination and patients with EBV-related diseases (n = 17) were examined. EBV genotype and strain were identified by sequence mutations within the Epstein-Barr nuclear antigen-2 region (EBNA-2) using DNA sequence analysis. Results: Both EBV genotypes, A and B, were detected (genotype A, 54/55, 98.2%; genotype B, 1/55, 1.8%). Within genotype A, GD1 was the most commonly detected strain (42/54, 77.7%), followed by B95-8 (9/54, 16.7%) and M-ABA (3/54, 5.6%). Genotype B, strain AG876, was found in one individual with CNS demyelinating disease. Conclusions: EBV genotype A and the GD1 strain were the common EBV genotypes isolated from individuals with and without CNS demyelinating disease, and in subjects with various EBV-related diseases. Although disease-specific genotypes or strains were not identified, this study provides useful insights into the molecular epidemiology of EBV infection in Australia. | |
dc.identifier.issn | 1423-0100 | |
dc.identifier.uri | http://hdl.handle.net/1885/64652 | |
dc.publisher | S Karger AG | |
dc.source | Intervirology | |
dc.subject | Keywords: Epstein Barr virus antigen 2; virus DNA; article; Australia; central nervous system; controlled study; demyelinating disease; Epstein Barr virus; Epstein Barr virus infection; genotype; human; major clinical study; nonhuman; nucleotide sequence; phylogeny Australia; Central nervous system demyelination; Epstein-Barr virus; Epstein-Barr virus-related diseases; Genotype; Multiple sclerosis; Sequencing | |
dc.title | Epstein-Barr virus genotypes and strains in central nervous system demyelinating disease and Epstein-Barr virus-related illnesses in Australia | |
dc.type | Journal article | |
local.bibliographicCitation.issue | 5 | |
local.bibliographicCitation.lastpage | 379 | |
local.bibliographicCitation.startpage | 372 | |
local.contributor.affiliation | Lay, Meav-Lang, Westmead Hospital | |
local.contributor.affiliation | Lucas, Robyn, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Toi, Cheryl, Westmead Hospital | |
local.contributor.affiliation | Ratnamohan, Mala, Institute of Clinical Pathology & Medical Research | |
local.contributor.affiliation | Ponsonby, Anne-Louise, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Dwyer, Dominic E, Westmead Hospital | |
local.contributor.affiliation | Ausimmune Investigator Group, The, Ausimmune Investigator Group | |
local.contributor.authoremail | u4002313@anu.edu.au | |
local.contributor.authoruid | Lucas, Robyn, u4002313 | |
local.contributor.authoruid | Ponsonby, Anne-Louise, u4021390 | |
local.description.notes | Imported from ARIES | |
local.identifier.absfor | 110804 - Medical Virology | |
local.identifier.absseo | 920404 - Disease Distribution and Transmission (incl. Surveillance and Response) | |
local.identifier.ariespublication | f5625xPUB975 | |
local.identifier.citationvolume | 55 | |
local.identifier.doi | 10.1159/000334693 | |
local.identifier.scopusID | 2-s2.0-84861456437 | |
local.identifier.thomsonID | 000304319000007 | |
local.identifier.uidSubmittedBy | f5625 | |
local.type.status | Published Version |