25-Hydroxyvitamin D Concentrations and Clostridium difficile Infection: A Meta-Analysis

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dc.contributor.authorFuruya-Kanamori, Luis
dc.contributor.authorWangdi, Kinley
dc.contributor.authorYakob, Laith
dc.contributor.authorMcKenzie, Samantha
dc.contributor.authorDoi, Suhail
dc.contributor.authorClark, J
dc.contributor.authorPaterson, David
dc.contributor.authorRiley, Thomas V
dc.contributor.authorClements, Archie
dc.date.accessioned2021-04-23T02:45:09Z
dc.date.issued2017
dc.date.updated2020-11-23T10:04:10Z
dc.description.abstractBackground: Well-known risk factors for Clostridium difficile infection (CDI) are exposure to antibiotics and gastric acid suppressants. Recent studies have provided some evidence of an association between hypovitaminosis D and the risk of CDI. Therefore, this meta-analysis aimed to pool all the existing evidence to investigate the association between 25-hydroxyvitamin D (25[OH]D) and CDI. Methods: A systematic search was conducted in 3 databases (PubMed, Embase, and Web of Sciences) for epidemiological studies that examined the association between mean 25(OH)D concentrations and CDI as well as between 25(OH)D status and CDI severity or recurrence. 25(OH)D status was defined as “lower” or “higher” at a threshold concentration of <20 or ≥20 ng/mL, respectively. Pooled effect sizes were computed using the inverse variance heterogeneity model of meta-analysis. Results: Eight publications (n = 4479 patients) were included in the meta-analysis. The mean concentration of 25(OH)D in patients with CDI was 3.54 ng/mL (95% confidence interval [CI], 0.39–6.89 ng/mL) lower than in patients without CDI. Patients with lower 25(OH)D status had a higher odds (odds ratio [OR], 1.61; 95% CI, 1.02–2.53) of developing severe CDI compared with those with a higher 25(OH)D status. No significant association was found between 25(OH)D status and CDI recurrence. Conclusion: The results of this meta-analysis suggest that lower mean concentrations of 25(OH)D were associated with CDI. A lower 25(OH)D status increased the odds of severe CDI but not of CDI recurrence.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0148-6071en_AU
dc.identifier.urihttp://hdl.handle.net/1885/230991
dc.language.isoen_AUen_AU
dc.publisherWileyen_AU
dc.rights© 2015 American Societyen_AU
dc.sourceJournal of Parenteral and enteral nutritionen_AU
dc.subjectClostridium difficileen_AU
dc.subjectinfectionen_AU
dc.subjectrecurrenceen_AU
dc.subjectseverityen_AU
dc.subjectvitamin Den_AU
dc.subject25-hydroxyvitamin Den_AU
dc.title25-Hydroxyvitamin D Concentrations and Clostridium difficile Infection: A Meta-Analysisen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue5en_AU
local.bibliographicCitation.lastpage895en_AU
local.bibliographicCitation.startpage890en_AU
local.contributor.affiliationFuruya Kanamori, Luis, College of Health and Medicine, ANUen_AU
local.contributor.affiliationWangdi, Kinley, College of Health and Medicine, ANUen_AU
local.contributor.affiliationYakob, Laith, London School of Hygiene & Tropical Medicineen_AU
local.contributor.affiliationMcKenzie, Samantha, University of Queenslanden_AU
local.contributor.affiliationDoi, Suhail, College of Health and Medicine, ANUen_AU
local.contributor.affiliationClark, J, Bond Universityen_AU
local.contributor.affiliationPaterson, David, University of Queenslanden_AU
local.contributor.affiliationRiley , Thomas V, Microbiology and Immunology, University of Western Australia, Nedlandsen_AU
local.contributor.affiliationClements, Archie, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu5127170@anu.edu.auen_AU
local.contributor.authoruidFuruya Kanamori, Luis, u5127170en_AU
local.contributor.authoruidWangdi, Kinley, u5608272en_AU
local.contributor.authoruidDoi, Suhail, u1005204en_AU
local.contributor.authoruidClements, Archie, u5611518en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor110309 - Infectious Diseasesen_AU
local.identifier.absfor111799 - Public Health and Health Services not elsewhere classifieden_AU
local.identifier.absfor110399 - Clinical Sciences not elsewhere classifieden_AU
local.identifier.absseo920399 - Indigenous Health not elsewhere classifieden_AU
local.identifier.absseo920599 - Specific Population Health (excl. Indigenous Health) not elsewhere classifieden_AU
local.identifier.absseo920109 - Infectious Diseasesen_AU
local.identifier.ariespublicationa383154xPUB7558en_AU
local.identifier.citationvolume41en_AU
local.identifier.doi10.1177/0148607115623457en_AU
local.identifier.scopusID2-s2.0-85026467935
local.identifier.thomsonID000406629400020
local.identifier.uidSubmittedBya383154en_AU
local.publisher.urlhttps://onlinelibrary.wiley.com/journal/19412444en_AU
local.type.statusPublished Versionen_AU

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