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Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

Date

Authors

Van Rooyen, Derrick

Gan, Lay

Yeh, Matthew

Haigh, W Geoffrey

Larter, Claire

Ioannou, George

Teoh, Narcissus

Farrell, Geoffrey

Publisher

Elsevier

Abstract

Background & Aims We have recently showed that hyperinsulinemia promotes hepatic free cholesterol (FC) accumulation in obese, insulin-resistant Alms1 mutant (foz/foz) mice with NASH. Here we tested whether cholesterol-lowering drugs reduce stress-activate

Keywords

Keywords: alanine aminotransferase; atorvastatin; ezetimibe; messenger RNA; monocyte chemotactic protein 1; myeloperoxidase; stress activated protein kinase; alanine aminotransferase blood level; animal cell; animal experiment; animal model; apoptosis; article; con Atorvastatin; Ezetimibe; Inflammatory recruitment; Lipotoxicity; Liver fibrosis

URI

http://hdl.handle.net/1885/77626

Collections

ANU Research Publications

Source

Journal of Hepatology

Type

Journal article

DOI

10.1016/j.jhep.2013.02.024

Restricted until

2037-12-31

Downloads

File

Description

01_Van Rooyen_Pharmacological_cholesterol_2013.pdf (2.8 MB)

02_Van Rooyen_Pharmacological_cholesterol_2013.pdf (2.8 MB)

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