Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

Van Rooyen, Derrick; Gan, Lay; Yeh, Matthew; Haigh, W Geoffrey; Larter, Claire; Ioannou, George; Teoh, Narcissus; Farrell, Geoffrey

Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

Date

2013

Authors

Van Rooyen, Derrick

Gan, Lay

Yeh, Matthew

Haigh, W Geoffrey

Larter, Claire

Ioannou, George

Teoh, Narcissus

Farrell, Geoffrey

Publisher

Elsevier

Abstract

Background & Aims We have recently showed that hyperinsulinemia promotes hepatic free cholesterol (FC) accumulation in obese, insulin-resistant Alms1 mutant (foz/foz) mice with NASH. Here we tested whether cholesterol-lowering drugs reduce stress-activate