Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome
Date
2013
Authors
Van Rooyen, Derrick
Gan, Lay
Yeh, Matthew
Haigh, W Geoffrey
Larter, Claire
Ioannou, George
Teoh, Narcissus
Farrell, Geoffrey
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Background & Aims We have recently showed that hyperinsulinemia promotes hepatic free cholesterol (FC) accumulation in obese, insulin-resistant Alms1 mutant (foz/foz) mice with NASH. Here we tested whether cholesterol-lowering drugs reduce stress-activate
Description
Keywords
Keywords: alanine aminotransferase; atorvastatin; ezetimibe; messenger RNA; monocyte chemotactic protein 1; myeloperoxidase; stress activated protein kinase; alanine aminotransferase blood level; animal cell; animal experiment; animal model; apoptosis; article; con Atorvastatin; Ezetimibe; Inflammatory recruitment; Lipotoxicity; Liver fibrosis
Citation
Collections
Source
Journal of Hepatology
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
Restricted until
2037-12-31