Cu 2 + -induced modification of the kinetics of A�(1-42)channels

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dc.contributor.authorBahadi, Randa
dc.contributor.authorFarrelly, Peter
dc.contributor.authorKenna, Bronwyn
dc.contributor.authorCurtain, Cyril
dc.contributor.authorMasters, Colin
dc.contributor.authorCappai, Roberto
dc.contributor.authorBarnham, Kevin
dc.contributor.authorKourie, Joseph
dc.date.accessioned2015-12-13T23:07:08Z
dc.date.available2015-12-13T23:07:08Z
dc.date.issued2003
dc.date.updated2015-12-12T08:08:02Z
dc.description.abstractWe found that the amyloid β peptide Aβ(1-42) is capable of interacting with membrane and forming heterogeneous ion channels in the absence of any added Cu2+ or biological redox agents that have been reported to mediate Aβ(1-42) toxicity. The Aβ(1-42)-
dc.identifier.issn0363-6143
dc.identifier.urihttp://hdl.handle.net/1885/86075
dc.publisherAmerican Physiological Society
dc.sourceAmerican Journal of Physiology - Cell Physiology
dc.subjectKeywords: amyloid beta protein; chelating agent; clioquinol; copper ion; prion protein; zinc ion; amyloid beta protein (1 42); amyloid beta-protein (1-42); chelating agent; clioquinol; copper; ion channel; peptide fragment; Alzheimer disease; article; binding site; Calcium homeostasis; Ion channel pathologies; Membrane injuries; Neurodegenerative diseases; Transitional metals
dc.titleCu 2 + -induced modification of the kinetics of A�(1-42)channels
dc.typeJournal article
local.bibliographicCitation.lastpageC880
local.bibliographicCitation.startpageC873
local.contributor.affiliationBahadi, Randa, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationFarrelly, Peter, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKenna, Bronwyn, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationCurtain, Cyril, University of Melbourne
local.contributor.affiliationMasters, Colin, University of Melbourne
local.contributor.affiliationCappai, Roberto, University of Melbourne
local.contributor.affiliationBarnham, Kevin, University of Melbourne
local.contributor.affiliationKourie, Joseph, College of Physical and Mathematical Sciences, ANU
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidBahadi, Randa, u4047662
local.contributor.authoruidFarrelly, Peter, u9909159
local.contributor.authoruidKenna, Bronwyn, u4030793
local.contributor.authoruidKourie, Joseph, u9111360
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor039999 - Chemical Sciences not elsewhere classified
local.identifier.ariespublicationMigratedxPub14815
local.identifier.citationvolume285
local.identifier.scopusID2-s2.0-0141791435
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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