Successful cholecalciferol desensitisation in a case of delayed hypersensitivity

Date

2019

Authors

Anantharajah, Anthea
Lamproglou, Anthony
Bridle, Sylvia
Chen, Weiwen
Tong, Winnie

Journal Title

Journal ISSN

Volume Title

Publisher

The Allergy and Immunology Society of Thailand

Abstract

Hypersensitivity to cholecalciferol (vitamin D3) or its active metabolite, calcitriol, is an exceedingly rare clinical phenomenon, with only 2 previously reported cases of suspected immediate hypersensitivity. Diagnosis of delayed drug hypersensitivity reactions is inherently difficult due to the lack of any robust in vitro diagnostic assay, particularly in those patients for whom provocation testing confers an unacceptable risk. In these situations, diagnosis relies on reproducible clinical manifestations following administration of the culprit agent, resolution upon its withdrawal and exclusion of other potential differential diagnoses. Based on these criteria, we propose the first reported case of delayed hypersensitivity to cholecalciferol successfully managed with a desensitisation protocol to pure cholecalciferol.

Description

Keywords

Drug hypersensitivity, Cholecalciferol, Calcitriol, Immunologic desensitisation

Citation

Source

Asia Pacific Allergy

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

Creative Commons Attribution licence

DOI

10.5415/apallergy.2019.9.e14

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