Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives
Date
2011
Authors
Wang, Shuxiang
Shao, Wenqing
Li, Hongdong
Liu, Cui
Wang, Ke
Zhang, Jinchao
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Elsevier
Abstract
Eight new gold(III) complexes (1-8) of 5-aryl-3-(pyridin-2-yl)-4,5- dihydropyrazole-1-carbothioamide have been synthesized and characterized by elemental analysis, molar conductivity, IR, UV,1H NMR,13C NMR, MS, and thermal analysis techniques. The cytotoxicity was tested by MTT assay. The results indicate that the complexes 1-8 exert cytotoxic effects against HeLa and A549 cell lines. Moreover, the complexes 1, 4, 5, 7 and 8 have higher cytotoxicity than cisplatin against HeLa cell line. It suggests that the substituent groups on benzene have important effect on cytotoxicity.
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Keywords: cisplatin; gold complex; pyrazole derivative; thioamide; article; cancer cell; carbon nuclear magnetic resonance; complex formation; controlled study; cytotoxicity; drug synthesis; human; human cell; infrared radiation; lung cancer; mass spectrometry; pro Cytotoxicity; Dihydropyrazole derivative; Gold(III) complex
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Source
European Journal of Medicinal Chemistry
Type
Journal article
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2037-12-31
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