Homocysteine, type 2 diabetes mellitus, and cognitive performance: The Main-Syracuse Study

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dc.contributor.authorRobbe, J-M
dc.contributor.authorElias, Merrill F
dc.contributor.authorBudge, Marc
dc.contributor.authorBrennan, Suzanne L
dc.contributor.authorElias, Penelope K
dc.date.accessioned2015-12-13T22:53:29Z
dc.date.issued2005
dc.date.updated2015-12-11T10:56:46Z
dc.description.abstractType 2 diabetes mellitus and higher total plasma homocysteine concentrations are each associated with an increased incidence of cardiovascular disease and with diminished cognitive performance. Relations between homocysteine concentrations and cardiovascular disease incidence are stronger in the presence of type 2 diabetes mellitus. Therefore, we hypothesized that relations between homocysteine concentrations and cognitive performance would be stronger in the presence of type 2 diabetes. We related homocysteine concentrations and cognitive performance on the Mini-Mental State Examination in 817 dementia and stroke-free participants of the Maine-Syracuse Study, 90 of whom were classified with type 2 diabetes mellitus. Regardless of statistical adjustment for age, sex, gender, vitamin co-factors (folate, vitamin B6, vitamin B12), cardiovascular disease risk factors, and duration and type of treatment for type 2 diabetes mellitus, statistically significant inverse associations between homocysteine concentrations and cognitive performance were observed for diabetic individuals. The weaker inverse associations between homocysteine concentrations and cognitive performance obtained for non-diabetic individuals were not robust to statistical adjustment for some covariates. Interactions between homocysteine concentrations and type 2 diabetes mellitus are observed such that associations between homocysteine and cognitive performance are stronger in the presence of diabetes.
dc.identifier.issn1434-6621
dc.identifier.urihttp://hdl.handle.net/1885/81835
dc.publisherWalter de Gruyter
dc.sourceClinical Chemistry and Laboratory Medicine
dc.subjectKeywords: cyanocobalamin; folic acid; homocysteine; pyridoxine; adult; age; aged; article; cardiovascular disease; cognition; controlled study; covariance; dementia; disease duration; female; gender; human; major clinical study; male; mental performance; mini menta Cardiovascular risk factors; Cognitive performance; Diabetes mellitus; Folate; Homocysteine; Vitamin B12; Vitamin B6
dc.titleHomocysteine, type 2 diabetes mellitus, and cognitive performance: The Main-Syracuse Study
dc.typeJournal article
local.bibliographicCitation.issue10
local.bibliographicCitation.lastpage1106
local.bibliographicCitation.startpage110
local.contributor.affiliationRobbe, J-M, Universite Lille
local.contributor.affiliationElias, Merrill F, University of Maine
local.contributor.affiliationBudge, Marc, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBrennan, Suzanne L, University of Maine
local.contributor.affiliationElias, Penelope K, University of Maine
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidBudge, Marc, u4592958
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110308 - Geriatrics and Gerontology
local.identifier.ariespublicationMigratedxPub10145
local.identifier.citationvolume43
local.identifier.doi10.1515/CCLM.2005.192
local.identifier.scopusID2-s2.0-27744466139
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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