Homocysteine, type 2 diabetes mellitus, and cognitive performance: The Main-Syracuse Study
dc.contributor.author | Robbe, J-M | |
dc.contributor.author | Elias, Merrill F | |
dc.contributor.author | Budge, Marc | |
dc.contributor.author | Brennan, Suzanne L | |
dc.contributor.author | Elias, Penelope K | |
dc.date.accessioned | 2015-12-13T22:53:29Z | |
dc.date.issued | 2005 | |
dc.date.updated | 2015-12-11T10:56:46Z | |
dc.description.abstract | Type 2 diabetes mellitus and higher total plasma homocysteine concentrations are each associated with an increased incidence of cardiovascular disease and with diminished cognitive performance. Relations between homocysteine concentrations and cardiovascular disease incidence are stronger in the presence of type 2 diabetes mellitus. Therefore, we hypothesized that relations between homocysteine concentrations and cognitive performance would be stronger in the presence of type 2 diabetes. We related homocysteine concentrations and cognitive performance on the Mini-Mental State Examination in 817 dementia and stroke-free participants of the Maine-Syracuse Study, 90 of whom were classified with type 2 diabetes mellitus. Regardless of statistical adjustment for age, sex, gender, vitamin co-factors (folate, vitamin B6, vitamin B12), cardiovascular disease risk factors, and duration and type of treatment for type 2 diabetes mellitus, statistically significant inverse associations between homocysteine concentrations and cognitive performance were observed for diabetic individuals. The weaker inverse associations between homocysteine concentrations and cognitive performance obtained for non-diabetic individuals were not robust to statistical adjustment for some covariates. Interactions between homocysteine concentrations and type 2 diabetes mellitus are observed such that associations between homocysteine and cognitive performance are stronger in the presence of diabetes. | |
dc.identifier.issn | 1434-6621 | |
dc.identifier.uri | http://hdl.handle.net/1885/81835 | |
dc.publisher | Walter de Gruyter | |
dc.source | Clinical Chemistry and Laboratory Medicine | |
dc.subject | Keywords: cyanocobalamin; folic acid; homocysteine; pyridoxine; adult; age; aged; article; cardiovascular disease; cognition; controlled study; covariance; dementia; disease duration; female; gender; human; major clinical study; male; mental performance; mini menta Cardiovascular risk factors; Cognitive performance; Diabetes mellitus; Folate; Homocysteine; Vitamin B12; Vitamin B6 | |
dc.title | Homocysteine, type 2 diabetes mellitus, and cognitive performance: The Main-Syracuse Study | |
dc.type | Journal article | |
local.bibliographicCitation.issue | 10 | |
local.bibliographicCitation.lastpage | 1106 | |
local.bibliographicCitation.startpage | 110 | |
local.contributor.affiliation | Robbe, J-M, Universite Lille | |
local.contributor.affiliation | Elias, Merrill F, University of Maine | |
local.contributor.affiliation | Budge, Marc, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Brennan, Suzanne L, University of Maine | |
local.contributor.affiliation | Elias, Penelope K, University of Maine | |
local.contributor.authoremail | repository.admin@anu.edu.au | |
local.contributor.authoruid | Budge, Marc, u4592958 | |
local.description.embargo | 2037-12-31 | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.absfor | 110308 - Geriatrics and Gerontology | |
local.identifier.ariespublication | MigratedxPub10145 | |
local.identifier.citationvolume | 43 | |
local.identifier.doi | 10.1515/CCLM.2005.192 | |
local.identifier.scopusID | 2-s2.0-27744466139 | |
local.identifier.uidSubmittedBy | Migrated | |
local.type.status | Published Version |
Downloads
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- 01_Robbe_Homocysteine,_type_2_diabetes_2005.pdf
- Size:
- 71.45 KB
- Format:
- Adobe Portable Document Format