Total and Regional Gray Matter Volume Is Not Related to APOE*E4 Status in a Community Sample of Middle-Aged Individuals

Cherbuin, Nicolas; Sachdev, Perminder Singh; Maller, Jerome; Meslin, Chantal; Mack, Holly; Wen, Wei; Easteal, Simon; Anstey, Kaarin

Total and Regional Gray Matter Volume Is Not Related to APOE*E4 Status in a Community Sample of Middle-Aged Individuals

Date

2008

Authors

Cherbuin, Nicolas

Sachdev, Perminder Singh

Maller, Jerome

Meslin, Chantal

Mack, Holly

Wen, Wei

Easteal, Simon

Anstey, Kaarin

Publisher

Oxford University Press

Abstract

Background. The APOE*E4 allele has been associated with greater gray matter atrophy and with Alzheimer's disease. The aim of this study was to investigate whether the relationship between cerebral gray matter atrophy and APOE*E4 genotype was also present

Keywords

Keywords: apolipoprotein E4; adult; allele; amygdaloid nucleus; article; brain atrophy; brain region; brain size; community sample; controlled study; female; gene frequency; genotype; gray matter; heterozygote; hippocampus; human; male; morphometrics; nuclear magne Amygdala; APOE; Cerebral atrophy; Hippocampus; MRI; Voxel-based morphometry

URI

http://hdl.handle.net/1885/34606

Collections

ANU Research Publications

Source

Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Type

Journal article

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Total and Regional Gray Matter Volume Is Not Related to APOE*E4 Status in a Community Sample of Middle-Aged Individuals

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