The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation

Date

2009

Authors

Pardo, Julian
Aguilo, Juan Ignacio
Anel, A
Martin, Praxedis
Joeckel, Lars
Borner, C
Wallich, R
Mullbacher, Arno
Froelich, Christopher J
Simon, Markus M

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

The granule exocytosis pathway of cytotoxic lymphocytes (Tc and NK cells) is critical for control of tumor development and viral infections. Granule-associated perforin and granzymes are key components in Tc cell-mediated function(s). On the basis of studies that showed granzymes A, B, C, K and M, to induce apoptosis in vitro, all granzymes were thought to also induce cell death in vivo. This review summarizes our present understanding of the biological processes elicited by purified granzyme A and granzyme as well as the processes induced by the more physiologically relevant cytotoxic cells secreting these proteases. The combined evidence supports the concept that the granule secretion pathway is not mono-specific but rather poly-functional including induction of pro-inflammatory cytokines, besides their widely appreciated apoptotic properties.

Description

Keywords

Keywords: cytokine; granzyme; granzyme A; granzyme B; granzyme c; granzyme H; granzyme k; granzyme m; unclassified drug; apoptosis; cell death; cell granule; cell type; cytokine release; cytotoxic lymphocyte; enzyme release; ex vivo study; exocytosis; human; in vit Cell death; Granule exocytosis; Granzymes; Inflammation; Perforin

Citation

Source

Microbes and Infection

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.micinf.2009.02.004

Restricted until

2037-12-31