Inflammatory myositis complicating hypocomplementemic urticarial vasculitis despite on-going immunosuppression
Date
2007
Authors
Chew, Gary
Gatenby, Paul
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Publisher
Springer
Abstract
We present a patient with previously diagnosed hypocomplementemic urticarial vasculitis syndrome, with skin, lung, and renal involvement, who presented with congestive cardiac failure. During the course of her hospitalization, she was also found to have profound proximal muscle weakness in both upper and lower limbs associated with raised creatinine kinase levels. A muscle biopsy was performed, which demonstrated evidence of an inflammatory myositis with vasculitis, which had returned despite on-going immunosuppression. This occurrence of a new autoimmune disease may well be an example of the "waste disposal" hypothesis.
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Keywords
Keywords: complement component C1q antibody; complement component C1r; complement component C1s; complement component C2; complement component C3; complement component C4; corticosteroid; creatine kinase; cyclophosphamide; diuretic agent; folic acid; mesna; methotr C1q; Complement; Hypocomplementemic urticarial vasculitis; Myositis
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Source
Clinical Rheumatology
Type
Journal article
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2037-12-31
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