F-18-florbetaben A beta imaging in mild cognitive impairment
Date
2013
Authors
Ong, Kevin
Villemagne, Victor L.
Bahar-Fuchs, Alex
Lamb, Fiona
Chetelat, Gael
Raniga, Parnesh
Mulligan, Rachel S.
Salvado, Olivier
Putz, Barbara
Roth, Katrin
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BioMed Central
Abstract
F-florbetaben and positron emission tomography were used to examine the relationships between b-amyloid (Ab) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).Methods:
Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Ab burden. Correlations were adjusted for age, gender and years of education.Results:
High A
b
burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r= -0.51,P= 0.0015) and hippocampal volume (r= 0.60,P= 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this
correlation was particularly associated with Ab burden.Conclusion: Higher Ab deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.
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Keywords
Alzheimers association workgroups, neurofibrillary tangles, amyloid deposition, white-matter, in-vivo, diagnostic guidelines, national institute, senile dementia, compound-b, disease
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Source
Alzheimer’s Research & Therapy 5.1 (2013)
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Journal article
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