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Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine

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dc.contributor.authorLee, Connie
dc.contributor.authorEaston, Christopher
dc.contributor.authorSavage, G Paul
dc.contributor.authorSimpson, Gregory Wayne
dc.date.accessioned2015-12-13T22:45:23Z
dc.date.issued2006
dc.date.updated2015-12-11T10:21:14Z
dc.description.abstractFour spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo- and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.
dc.identifier.issn1551-7004
dc.identifier.urihttp://hdl.handle.net/1885/79744
dc.publisherARKAT Foundation
dc.sourceARKIVOC
dc.source.urihttp://www.arkat-usa.org/home.aspx?VIEW=MANUSCRIPT&MSID=1605
dc.subjectKeywords: Acetylcholinesterase; Alzheimer's disease; Cycloadditions; Isoxazolines; Nitrile oxides; Quinuclidine
dc.titleSynthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine
dc.typeJournal article
local.bibliographicCitation.issueiii
local.bibliographicCitation.lastpage183
local.bibliographicCitation.startpage175
local.contributor.affiliationLee, Connie, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationEaston, Christopher, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationSavage, G Paul, CSIRO Molecular and Health Technologies
local.contributor.affiliationSimpson, Gregory Wayne, CSIRO
local.contributor.authoruidLee, Connie, u9804802
local.contributor.authoruidEaston, Christopher, u9500570
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.ariespublicationMigratedxPub8126
local.identifier.citationvolume2006
local.identifier.scopusID2-s2.0-27744436125
local.type.statusPublished Version

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