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Risk factors of transition from normal cognition to mild cognitive disorder: The PATH trough Life study.

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dc.contributor.authorCherbuin, Nicolas
dc.contributor.authorMeslin, Chantal
dc.contributor.authorKumar, Rajeev
dc.contributor.authorJacomb, Trish
dc.contributor.authorEasteal, Simon
dc.contributor.authorChristensen, Helen
dc.contributor.authorSachdev, Perminder Singh
dc.contributor.authorAnstey, Kaarin
dc.date.accessioned2015-12-10T22:12:22Z
dc.date.issued2009
dc.date.updated2016-02-24T10:37:28Z
dc.description.abstractAims: The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD). Methods: A total of 2,082 individuals, aged 60-64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs. Results: The main predictors of conversion to MCI and to other mild cognitive disorders were past alcohol intake, current anxiety and depression medication, increased systolic blood pressure, and past smoking. Conclusion: Participants with a history of smoking or harmful alcohol consumption, hypertension, or who took medication for anxiety or depression were at increased risk of transitioning to MCI or any MCD. Strategies targeted at managing the above risk factors may have benefits in preventing mild cognitive decline in relatively healthy middle-aged individuals living in the community.
dc.identifier.issn1420-8008
dc.identifier.urihttp://hdl.handle.net/1885/49621
dc.publisherS Karger AG
dc.sourceDementia and Geriatric Cognitive Disorders
dc.subjectKeywords: antidepressant agent; antilipemic agent; apolipoprotein E; adult; alcohol consumption; antihypertensive therapy; anxiety; arthritis; article; body mass; cigarette smoking; cognition; controlled study; depression; diabetes mellitus; diastolic blood pressur Alcohol; BMI; Depression; Hypertension; Mild cognitive impairment
dc.titleRisk factors of transition from normal cognition to mild cognitive disorder: The PATH trough Life study.
dc.typeJournal article
local.bibliographicCitation.issue1
local.bibliographicCitation.lastpage55
local.bibliographicCitation.startpage47
local.contributor.affiliationCherbuin, Nicolas, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMeslin, Chantal, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKumar, Rajeev, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationJacomb, Trish, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationEasteal, Simon, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationChristensen, Helen, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSachdev, Perminder Singh, University of New South Wales (Prince of Wales Hospital)
local.contributor.affiliationAnstey, Kaarin, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidCherbuin, Nicolas, u3184049
local.contributor.authoruidMeslin, Chantal, u4028155
local.contributor.authoruidKumar, Rajeev, u3923137
local.contributor.authoruidJacomb, Trish, u8511103
local.contributor.authoruidEasteal, Simon, u8200596
local.contributor.authoruidChristensen, Helen, u8804902
local.contributor.authoruidAnstey, Kaarin, u4038535
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor111714 - Mental Health
local.identifier.absseo920410 - Mental Health
local.identifier.ariespublicationU4146231xPUB189
local.identifier.citationvolume28
local.identifier.doi10.1159/000229025
local.identifier.scopusID2-s2.0-67650996204
local.identifier.thomsonID000269132700007
local.type.statusPublished Version

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