Reversal of regioselectivity and enhancement of rates of nitrile oxide cycloadditions through transient attachment of dipolarophiles to cyclodextrins
Date
2006
Authors
Barr, Lorna
Lincoln, Stephen F
Easton, Christopher
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Publisher
Wiley-VCH Verlag GMBH
Abstract
The reactions of nitrile oxides with monosubstituted dipolarophiles, such as propiolamide, typically afford proportionally 80% or more of the 3,5-disubstituted cycloadducts. By contrast, the reactions of 6 A-deoxy-6A-propynamido-β-cyclodextrin with 4-ter
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Keywords
Keywords: Addition reactions; Chemical bonds; Esters; Hydrolysis; Reaction kinetics; Crotonic acid; Inclusion compounds; Molecular reactors; Regioisomers; Regioselectivity; Nitrogen compounds; acrylic acid; acrylic acid derivative; benzonitrile; crotonic acid deriv Cycloaddition; Cyclodextrins; Inclusion compounds; Molecular reactors; Regioselectivity
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Source
Chemistry, A European Journal
Type
Journal article
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2037-12-31
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