Host genetics in malaria: lessons from mouse studies

dc.contributor.authorHuang, Hong Ming
dc.contributor.authorMcMorran, Brendan
dc.contributor.authorFoote, Simon
dc.contributor.authorBurgio, Gaetan
dc.date.accessioned2022-11-14T03:10:50Z
dc.date.issued2018
dc.date.updated2021-11-28T07:27:41Z
dc.description.abstractMalaria remains a deadly parasitic disease caused by Plasmodium, claiming almost half a million lives every year. While parasite genetics and biology are often the major targets in many studies, it is becoming more evident that host genetics plays a crucial role in the outcome of the infection. Similarly, Plasmodium infections in mice also rely heavily on the genetic background of the mice, and often correlate with observations in human studies, due to their high genetic homology with humans. As such, murine models of malaria are a useful tool for understanding host responses during Plasmodium infections, as well as dissecting host-parasite interactions through various genetic manipulation techniques. Reverse genetic approach such as quantitative trait loci studies and random mutagenesis screens have been employed to discover novel host genes that affect malaria susceptibility in mouse models, while other targeted studies utilize mouse models to validate observation from human studies. Herein, we review the findings from the past and present studies on murine models of hepatic and erythrocytic stages of malaria and speculate on how the current mouse models benefit from the recent development in CRISPR/Cas9 gene editing technology.en_AU
dc.description.sponsorshipAustralian Society of Parasitology (ASP), OzEMalaR, National Collaborative Research Infrastructure Strategy (NCRIS), the Education Investment Fund from the Department of Education and Training, the Australian Phenomics Network, Howard Hughes Medical Institute and the Bill and Melinda Gates Foundation, the Japan Society for Promotion of Science (JSPS) and the Australian Research Council (ARC) for the funding, and Lora Starrs for the proofreading of the manuscript.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0938-8990en_AU
dc.identifier.urihttp://hdl.handle.net/1885/279403
dc.language.isoen_AUen_AU
dc.publisherSpringeren_AU
dc.rights© 2018 The authorsen_AU
dc.sourceMammalian Genomeen_AU
dc.titleHost genetics in malaria: lessons from mouse studiesen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue7-8en_AU
local.bibliographicCitation.lastpage522en_AU
local.bibliographicCitation.startpage507en_AU
local.contributor.affiliationHuang, Hong (Ming), College of Health and Medicine, ANUen_AU
local.contributor.affiliationMcMorran, Brendan, College of Health and Medicine, ANUen_AU
local.contributor.affiliationFoote, Simon, College of Health and Medicine, ANUen_AU
local.contributor.affiliationBurgio, Gaetan, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu5717222@anu.edu.auen_AU
local.contributor.authoruidHuang, Hong (Ming), u5717222en_AU
local.contributor.authoruidMcMorran, Brendan, u5267721en_AU
local.contributor.authoruidFoote, Simon, u5697711en_AU
local.contributor.authoruidBurgio, Gaetan, u5727247en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor320211 - Infectious diseasesen_AU
local.identifier.absfor320704 - Medical parasitologyen_AU
local.identifier.absfor320407 - Innate immunityen_AU
local.identifier.absseo280103 - Expanding knowledge in the biomedical and clinical sciencesen_AU
local.identifier.absseo200105 - Treatment of human diseases and conditionsen_AU
local.identifier.ariespublicationa383154xPUB9646en_AU
local.identifier.citationvolume29en_AU
local.identifier.doi10.1007/s00335-018-9744-9en_AU
local.identifier.scopusID2-s2.0-85044462514
local.identifier.uidSubmittedBya383154en_AU
local.publisher.urlhttps://link.springer.com/en_AU
local.type.statusPublished Versionen_AU

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