Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos
Date
2009
Authors
Linterman, Michelle
Rigby, Robert
Wong, Raphael
Silva, Diego
Withers, David
Anderson, Graham
Verma, Naresh
Brink, Robert
Hutloff, Andreas
Goodnow, Christopher
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Cell Press
Abstract
During evolutionary adaptation in the immune system, host defense is traded off against autoreactivity. Signals through the costimulatory receptor CD28 enable T cells to respond specifically to pathogens, whereas those through the related costimulatory r
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Keywords
Keywords: CD28 antigen; interleukin 2; ligand; messenger RNA; transcription factor FOXP3; ubiquitin protein ligase E3; allele; animal cell; animal experiment; animal tissue; antibody response; antigen expression; article; B lymphocyte; cell compartmentalization; ce MOLIMMUNO
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Source
Immunity
Type
Journal article
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2037-12-31
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