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Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

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Date

2009

Authors

Linterman, Michelle
Rigby, Robert
Wong, Raphael
Silva, Diego
Withers, David
Anderson, Graham
Verma, Naresh
Brink, Robert
Hutloff, Andreas
Goodnow, Christopher

Journal Title

Journal ISSN

Volume Title

Publisher

Cell Press

Abstract

During evolutionary adaptation in the immune system, host defense is traded off against autoreactivity. Signals through the costimulatory receptor CD28 enable T cells to respond specifically to pathogens, whereas those through the related costimulatory r

Description

Keywords

Keywords: CD28 antigen; interleukin 2; ligand; messenger RNA; transcription factor FOXP3; ubiquitin protein ligase E3; allele; animal cell; animal experiment; animal tissue; antibody response; antigen expression; article; B lymphocyte; cell compartmentalization; ce MOLIMMUNO

Citation

URI

http://hdl.handle.net/1885/50983

Collections

ANU Research Publications

Source

Immunity

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.immuni.2008.12.015

Restricted until

2037-12-31

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Description
01_Linterman_Roquin_Differentiates_the_2009.pdf (1.84 MB)

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