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Cellular function of p70S6K: A role in regulating cell motility

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dc.contributor.authorCrouch, Michael F
dc.date.accessioned2015-12-13T23:18:29Z
dc.date.issued2000
dc.date.updated2015-12-12T08:56:59Z
dc.description.abstractThe 70 kDa ribosomal S6 kinase (p70(S6K)) is activated by numerous mitogens, growth factors and hormones. Activation of p70(S6K) occurs through phosphorylation at a number of sites and the primary target of the activated kinase is the 40S ribosomal protein S6, a major component of the machinery involved in protein synthesis in mammalian cells. In addition to its involvement in regulating translation, p70(S6K) activation has been implicated in cell cycle control and neuronal cell differentiation. Recent data obtained in this laboratory suggests that p70(S6K) may also function in regulating cell motility, a cellular response that is important in tumour metastases, the immune response and tissue repair. The present paper reviews the regulation and cellular function of p70(S6K) and proposes a novel function of p70(S6K) in regulating cell motility.
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/90198
dc.publisherBlackwell Publishing Ltd
dc.sourceImmunology and Cell Biology
dc.subjectKeywords: guanine nucleotide binding protein; phosphatidylinositol 3 kinase; rapamycin; wortmannin; ribosome protein; S6 kinase; cell function; cell migration; cell motility; conference paper; enzyme activity; immune response; metastasis; protein synthesis; ribosom Cytoskeleton; Migration; P70(S6K)
dc.titleCellular function of p70S6K: A role in regulating cell motility
dc.typeJournal article
local.bibliographicCitation.lastpage451
local.bibliographicCitation.startpage447
local.contributor.affiliationCrouch, Michael F, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidCrouch, Michael F, u8806251
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor111299 - Oncology and Carcinogenesis not elsewhere classified
local.identifier.ariespublicationMigratedxPub20496
local.identifier.citationvolume78
local.identifier.doi10.1046/j.1440-1711.2000.00928.x
local.identifier.scopusID2-s2.0-0033624269
local.type.statusPublished Version

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