Follicular B helper T cells in antibody responses and autoimmunity

Date

2005

Authors

Garcia De Vinuesa, Maria Carola
Tangye, Stuart G
Moser, Bernhard
Mackay, Charles R

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4+ T cells in the tonsils and memory CD4+ T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper 1 and T helper 2 cells and have been denoted follicular B helper T cells. Here, we outline the central role of this subset in normal and pathological immune responses.

Description

Keywords

Keywords: CD40 ligand; chemokine receptor CCR5; interleukin 10; transcription factor; antibody response; autoimmunity; B lymphocyte; cell differentiation; cell growth; cell maturation; cell migration; cell survival; cellular immunity; gene expression; gene mutation

Citation

Source

Nature Reviews Immunology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

Restricted until

2037-12-31