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Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model

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dc.contributor.authorArkell, Ruth
dc.contributor.authorWaters, James M
dc.contributor.authorLindo, Jessica E
dc.contributor.authorCowin, Allison J
dc.date.accessioned2015-12-10T23:09:51Z
dc.date.issued2010
dc.date.updated2016-02-24T08:33:05Z
dc.description.abstractRegeneration of cells, tissues, and organs has long captured the attention of researchers for its obvious potential benefits in biomedical applications. Although mammals are notoriously poor at regeneration compared with many lower-order species, the hair follicle, paradoxically a defining characteristic of mammals, is capable of regeneration following partial amputation. To investigate the role of a negative regulator of wound healing, flightless I (Flii), on hair follicle regeneration, the bulbar region of vibrissae from rats as well as strains of mice expressing low (Flii+/-), normal (Flii+/+), and high (FLIITg/Tg) levels of Flii were surgically amputated, and then allowed to regenerate in vivo. Macroscopic and histological assessment of the regeneration process revealed impaired or delayed regenerative potential in Flii / follicles. Regenerated follicles expressing high levels of Flii (FLIITg/Tg) produced significantly longer terminal hair fibers. Immunohistochemical analysis was used to characterize the pattern of expression of Flii, as well as markers of hair follicle development and wound healing-associated factors during hair follicle regeneration. These studies confirmed that Flii appears to have a positive role in the regeneration of hair follicles, contrary to its negative influence on wound healing in skin.
dc.identifier.issn0022-202X
dc.identifier.urihttp://hdl.handle.net/1885/63469
dc.publisherNature Publishing Group
dc.sourceThe Journal of Investigative Dermatology
dc.subjectKeywords: cytoskeleton protein; protein flightless 1; unclassified drug; amputation; animal cell; animal experiment; animal tissue; article; cell maturation; cell regeneration; controlled study; hair follicle; histopathology; immunohistochemistry; in vivo study; ma
dc.titleRegeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model
dc.typeJournal article
local.bibliographicCitation.startpage10
local.contributor.affiliationArkell, Ruth, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWaters, James M, Women's and Children's Health Research Institute
local.contributor.affiliationLindo, Jessica E, Women's and Children's Health Research Institute
local.contributor.affiliationCowin, Allison J, Women's and Children's Health Research Institute
local.contributor.authoremailu4350791@anu.edu.au
local.contributor.authoruidArkell, Ruth, u4350791
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060403 - Developmental Genetics (incl. Sex Determination)
local.identifier.absseo920117 - Skin and Related Disorders
local.identifier.ariespublicationf2965xPUB811
local.identifier.citationvolumePublished online 30 December 2010
local.identifier.doi10.1038/jid.2010.393
local.identifier.scopusID2-s2.0-79952766175
local.identifier.thomsonID000289035800010
local.identifier.uidSubmittedByf2965
local.type.statusPublished Version

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