Elucidation of piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of a-pyridone ring formation
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Liu, Qian
Yao, Fen
Chooi, Yit-Heng
Kang, Qianjin
Xu, Wei
Li, Yanran
Shao, Yucheng
Shi, Yuefeng
Deng, Zixin
Tang, Yi
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Elsevier
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Piericidins are a class of α-pyridone antibiotics that inhibit mitochondrial respiratory chain and exhibit antimicrobial, antifungal, and antitumor activities. Sequential analysis of Streptomyces piomogeues var. Hangzhouwanensis genome revealed six modul
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Chemistry and Biology
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2037-12-31
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