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Mclip: Motif detection based on cliques of gapped local profile-to-profile alignments

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dc.contributor.authorFrickey, Tancred
dc.contributor.authorWeiller, Georg
dc.date.accessioned2015-12-07T22:41:05Z
dc.date.issued2007
dc.date.updated2015-12-07T10:57:09Z
dc.description.abstractSummary: A multitude of motif-finding tools have been published, which can generally be assigned to one of three classes: expectation-maximization, Gibbs-sampling or enumeration. Irrespective of this grouping, most motif detection tools only take into account similarities across ungapped sequence regions, possibly causing short motifs located peripherally and in varying distance to a 'core' motif to be missed. We present a new method, adding to the set of expectation-maximization approaches, that permits the use of gapped alignments for motif elucidation.
dc.identifier.issn1367-4803
dc.identifier.urihttp://hdl.handle.net/1885/24149
dc.publisherOxford University Press
dc.sourceBioinformatics
dc.subjectKeywords: Arabidopsis; article; computer interface; computer program; gene expression profiling; Internet; microarray analysis; nonhuman; priority journal; scoring system; sequence alignment; sequence analysis; Algorithms; Base Sequence; Molecular Sequence Data; Se
dc.titleMclip: Motif detection based on cliques of gapped local profile-to-profile alignments
dc.typeJournal article
local.bibliographicCitation.issue4
local.bibliographicCitation.lastpage503
local.bibliographicCitation.startpage502
local.contributor.affiliationFrickey, Tancred, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWeiller, Georg, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidFrickey, Tancred, u4285348
local.contributor.authoruidWeiller, Georg, u9009731
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060407 - Genome Structure and Regulation
local.identifier.ariespublicationu9204316xPUB30
local.identifier.citationvolume23
local.identifier.doi10.1093/bioinformatics/btl601
local.identifier.scopusID2-s2.0-33847292770
local.type.statusPublished Version

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