Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice
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Authors
Larter, Claire
Yeh, Matthew
Van Rooyen, Derrick
Teoh, Narcissus
Brooling, John
Hou, Jing Yun
Williams, Jacqueline
Clyne, Matthew
Nolan, Christopher
Farrell, Geoffrey
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Blackwell Publishing Ltd
Abstract
Background and Aims: We previously reported that steatohepatitis develops in obese, hypercholesterolemic, diabetic foz/foz mice fed a high-fat (HF) diet for 12 months. We now report earlier onset of steatohepatitis in relation to metabolic abnormalities,
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Journal of Gastroenterology and Hepatology