Structural basis for cofactor-independent dioxygenation of N -heteroaromatic compounds at the α/β-hydrolase fold

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dc.contributor.authorSteiner, Roberto A
dc.contributor.authorJanssen, Helge J
dc.contributor.authorRoversi, Pietro
dc.contributor.authorOakley, Aaron
dc.contributor.authorFetzner, Susanne
dc.date.accessioned2015-12-10T22:32:48Z
dc.date.issued2010
dc.date.updated2016-02-24T10:23:17Z
dc.description.abstractEnzymatic catalysis of oxygenation reactions in the absence of metal or organic cofactors is a considerable biochemical challenge. The CO-forming 1-H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (HOD) from Arthrobacter nitroguajacolicus Rü61a and 1-H-3-hydr
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/1885/55935
dc.publisherNational Academy of Sciences (USA)
dc.sourcePNAS - Proceedings of the National Academy of Sciences of the United States of America
dc.subjectKeywords: 1h 3 hydroxy 4 oxoquinaldine 2,4 dioxygenase; 1h 3 hydroxy 4 oxoquinoline 2,4 dioxygenase; dioxygenase; hydrolase; unclassified drug; Arthrobacter; Arthrobacter nitroguajacolicus; article; catalysis; crystal structure; enzyme active site; enzyme activity; Oxygen chemistry; Oxygenase; Structural enzymology
dc.titleStructural basis for cofactor-independent dioxygenation of N -heteroaromatic compounds at the α/β-hydrolase fold
dc.typeJournal article
local.bibliographicCitation.issue2
local.bibliographicCitation.lastpage662
local.bibliographicCitation.startpage657
local.contributor.affiliationSteiner, Roberto A, King's College London
local.contributor.affiliationJanssen, Helge J, Westfalian Wilhelms-University
local.contributor.affiliationRoversi, Pietro, University of Oxford
local.contributor.affiliationOakley, Aaron, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationFetzner, Susanne, Westfalische Wilhelms-University
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidOakley, Aaron, u4134401
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor030499 - Medicinal and Biomolecular Chemistry not elsewhere classified
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationu4005981xPUB345
local.identifier.citationvolume107
local.identifier.doi10.1073/pnas.0909033107
local.identifier.scopusID2-s2.0-76249120623
local.identifier.uidSubmittedByu4005981
local.type.statusPublished Version

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