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Effects of propofol on GABA(A) channel conductance in rat-cultured hippocampal neurons

Date

Authors

Eghbali, Mansoureh

Gage, Peter

Birnir, Bryndis

Publisher

Elsevier

Abstract

Channels were activated, in ripped-off patches from rat-cultured hippocampal neurons, by propofol alone, propofol plus 0.5 μM GABA (γ-aminobutyric acid) or GABA alone. The propofol-activated currents were chloride-selective, showed outward-rectification

Keywords

Keywords: 4 aminobutyric acid; diazepam; propofol; 4 aminobutyric acid; 4 aminobutyric acid A receptor; benzodiazepine receptor affecting agent; chloride channel; diazepam; intravenous anesthetic agent; propofol; animal cell; article; cell culture; conductance; hip Anaesthetic; Benzodiazepine; Extrasynaptic receptor; GABA (?-aminobutyric acid); GABAA receptor; Inhibition

URI

http://hdl.handle.net/1885/88536

Collections

ANU Research Publications

Source

European Journal of Pharmacology

Type

Journal article

DOI

10.1016/S0014-2999(03)01641-8