Taxane Diterpene Synthesis Studies. Part 1: Chemoenzymatic and Enantiodivergent Routes to AB-ring Substructures of Taxoids and  ent -Taxoids

Banwell, Martin; Darmos, Penny; Hockless, David

Taxane Diterpene Synthesis Studies. Part 1: Chemoenzymatic and Enantiodivergent Routes to AB-ring Substructures of Taxoids and ent -Taxoids

Date

2004

Authors

Banwell, Martin

Darmos, Penny

Hockless, David

Publisher

CSIRO Publishing

Abstract

The microbially derived cis-1,2-dihydrocatechol 2 has been converted, via reaction sequences including Diels-Alder cycloaddition and anionic oxy-Cope rearrangement steps, into enantiopure bicyclo[5.3.1]undecenes 21 and 34, which correspond to AB-ring substructures of ent-taxoids and taxoids, respectively.