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Complexity generation in fungal polyketide biosynthesis: A spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin

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Date

2013

Authors

Cacho, Ralph A
Chooi, Yit-Heng
Zhou, Hui
Tang, Yi

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

Griseofulvin (1) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes. Formation of the spirocycle, or the grisan scaffold, from a benzophenone precursor is critical for the activity of 1. In this study, we have systematically

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Keywords

Citation

URI

http://hdl.handle.net/1885/81536

Collections

ANU Research Publications

Source

ACS chemical biology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/cb400541z

Restricted until

2037-12-31

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01_Cacho_Complexity_generation_in_2013.pdf (2.63 MB)

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