Complexity generation in fungal polyketide biosynthesis: A spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin
Date
2013
Authors
Cacho, Ralph A
Chooi, Yit-Heng
Zhou, Hui
Tang, Yi
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American Chemical Society
Abstract
Griseofulvin (1) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes. Formation of the spirocycle, or the grisan scaffold, from a benzophenone precursor is critical for the activity of 1. In this study, we have systematically
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ACS chemical biology
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Journal article
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2037-12-31
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