Preparation of some angularly substituted and highly functionalized quinolizidines as building blocks for the synthesis of various alkaloids and related scaffolds of medicinal interest

Date

2009

Authors

Bissember, Alexander
Banwell, Martin

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

The epimeric forms of the angularly substituted quinolizidine 6, representing potentially useful building blocks for the synthesis of various alkaloids, have been prepared via a pathway involving two consecutive ring-closing metathesis reactions. Variously hydroxy-protected derivatives (21, 22, and 26-29) of these compounds have also been generated.

Description

Keywords

Keywords: alkaloid derivative; quinolizidine derivative; article; chemical analysis; chemical reaction; chemical structure; drug synthesis; priority journal; ring closing metathesis Alkaloids; Fasicularin; Quinolizidines; Ring-closing metathesis; Vinylation

Citation

Source

Tetrahedron

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.tet.2009.07.067

Restricted until

2037-12-31