Heated and humidified inspired gas through heated humidifiers in comparison to non-heated and non-humidified gas in hospitalised neonates receiving respiratory support (Protocol)

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To determine the effects of heated and humidified inspiratory gas through heated humidifiers (HHs) compared to non-heated andnon-humidified inspiratory gas on mor tality and morbidity in neonates receiving respiratory support during resuscitation immediatelyafter birth and after the initial resuscitation.Comparison 1: Heated and humidified inspiratory gas through heated humidifiers (HHs) compared to non-heated and non-humidified inspiratory gas on mortality and morbidity in neonates receiving respiratory support during resuscitation immedi-ately after birth.Proposed subgroup analyses:• Gestational age: < 30 weeks, 30-36 weeks, 37 wee ks and over;• Mode of respiratory support (e. g. mask continuous positive airway pressure, mask intermittent positive pressure ventilation,endotracheal intermittent positive pressure ventilation).Comparison 2: Heated and humidified inspiratory gas through heated humidifiers (HHs) compared to non-heated and non-humidified inspiratory gas o n mortality and morbidity in neonates receiving respiratory support after initial resuscitation.Proposed subgroup analyses:• Gestational age: < 30 weeks, 30-36 weeks, 37 wee ks and over;• Mode of respiratory support (e. g. low flow oxygen, high flow nasal cannula, nasal continuous positive airway pressure, nasalintermittent positive pressure ventilation, conventional mechanical ventilation, high frequency ventilation). • Sites of intervention: Neonatal intensive care unit (NICU), operating theatre or neonatal transport.• Underlying respiratory conditions: respiratory distress syndrome, apnoea of prematurity, meconium aspiration syndrome,perinatal asphyxia, pneumonia. Show more