Stromal Cell Subsets Directing Neonatal Spleen Regeneration

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dc.contributor.authorTan, Jonathan
dc.contributor.authorWatanabe, Takeshi
dc.date.accessioned2021-09-21T06:50:14Z
dc.date.available2021-09-21T06:50:14Z
dc.date.issued2017
dc.date.updated2020-11-23T11:11:05Z
dc.description.abstractDevelopment of lymphoid tissue is determined by interactions between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer (LTi) cells. A failure for LTo to receive appropriate activating signals during embryogenesis through lymphotoxin engagement leads to a complete cessation of lymph node (LN) and Peyer’s patch development, identifying LTo as a key stromal population for lymphoid tissue organogenesis. However, little is known about the equivalent stromal cells that induce spleen development. Here, by dissociating neonatal murine spleen stromal tissue for re-aggregation and transplant into adult mouse recipients, we have identified a MAdCAM-1+CD31+CD201+ spleen stromal organizer cell-type critical for new tissue formation. This finding provides an insight into the regulation of post-natal spleen tissue organogenesis, and could be exploited in the development of spleen regenerative therapiesen_AU
dc.description.sponsorshipThis work was supported by MEXT, Japan (Grant-in-Aid for Scientific Research on Priority Areas 19059015 to T.W.) and NHMRC, Australia (CJ Martin Biomedical Postdoctoral Fellowship 1013553 to J.K.H.T).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2045-2322en_AU
dc.identifier.urihttp://hdl.handle.net/1885/248286
dc.language.isoen_AUen_AU
dc.provenanceThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.en_AU
dc.publisherNature Publishing Groupen_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1013553en_AU
dc.rights© The Author(s) 2017en_AU
dc.rights.licenseCreative Commons License (Attribution 4.0 International)en_AU
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceScientific Reportsen_AU
dc.titleStromal Cell Subsets Directing Neonatal Spleen Regenerationen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.contributor.affiliationTan, Jonathan, College of Science, ANUen_AU
local.contributor.affiliationWatanabe, Takeshi, Kyoto Universityen_AU
local.contributor.authoruidTan, Jonathan, u3359371en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor110704 - Cellular Immunologyen_AU
local.identifier.absfor110799 - Immunology not elsewhere classifieden_AU
local.identifier.absseo920108 - Immune System and Allergyen_AU
local.identifier.ariespublicationa383154xPUB6328en_AU
local.identifier.citationvolume7en_AU
local.identifier.doi10.1038/srep40401en_AU
local.identifier.scopusID2-s2.0-85008967572
local.identifier.thomsonID000391375700001
local.publisher.urlhttp://www.nature.com/en_AU
local.type.statusPublished Versionen_AU

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