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Glutathione transferase M2 variants inhibit ryanodine receptor function in adult mouse cardiomyocytes

Samarasinghe Ranaweera Gamarachchilage, Shalitha (Kaveenda); Liu, Dan; Tummala, Padmaja; Cappello, Jean; Pace, Suzy M; Arnolda, Leonard; Casarotto, Marco; Dulhunty, Angela; Board, Philip

Description

Release of Ca2+ from the sarcoplasmic reticulum (SR) through the cardiac ryanodine receptor (RyR2) is an essential step in cardiac excitation-contraction coupling. Excess Ca2+ release due to overactive RyR2 can cause arrhythmia that can lead to cardiac arrest. Fragments derived from the carboxy-terminal domain of human glutathione transferase M2 (GSTM2C) specifically inhibit RyR2 activity. Our aim was to further improve this inhibition by mutagenesis and to assess the therapeutic potential of...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/98510
Source: Biochemical Pharmacology
DOI: 10.1016/j.bcp.2015.08.004

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