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Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

Ma, Cindy; Wong, Natalie; Rao, Geetha; Avery, Danielle T; Torpy, James; Hambridge, Thomas; Bustamante, Jacinta; Okada , Satoshi; Stoddard, Jennifer L.; Deenick, Elissa; Pelham, Simon J.; Payne, Kathryn; Boisson-Dupuis, Stephanie; Puel, Anne; Kobayashi, Masao; Arkwright, Peter D; Kilic, Sara Sebnem; El Baghdadi, Jamila; Nonoyama, Shigeaki; Minegishi, Yoshiyuki; Mahdaviani, Seyed Alireza; Mansouri, Davood; Bousfiha, Aziz; Blincoe, Annaliesse K.; French, Martyn A.; Hsu, Peter; Campbell, Dianne E.; Stormon, Michael; Wong, Melanie; Adelstein, Stephen; Smart, Joanne M.; Fulcher , David A.; Cook, Matthew; Phan, Tri Giang; Stepensky, Polina; Boztug, Kaan; Kansu, Aydan; Ikinciogullari, Aydan; Baumann, Ulrich; Beier, Rita; Roscioli, Tony; Ziegler, John B; Gray, Paul; Picard, Capucine; Grimbacher, B.; Warnatz, Klaus; Holland, Steven M.; Casanova, Jean-Laurent; Uzel, G; Tangye, Stuart


Background: Follicular helper T (T<inf>FH</inf>) cells underpin T cell-dependent humoral immunity and the success of most vaccines. T<inf>FH</inf> cells also contribute to human immune disorders, such as autoimmunity, immunodeficiency, and malignancy. Understanding the molecular requirements for the generation and function of T<inf>FH</inf> cells will provide strategies for targeting these cells to modulate their behavior in the setting of these immunologic abnormalities. Objective: We sought...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Allergy and Clinical Immunology
DOI: 10.1016/j.jaci.2015.05.036


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