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Colchicine causes excessive ocular growth and myopia in chicks

Fischer, A J; Morgan, Ian; Stell, William K


Colchicine has been reported to destroy ganglion cells (GCs) in the retina of hatchling chicks. We tested whether colchicine influences normal ocular growth and form-deprivation myopia, and whether it affects cells other than GCs. Colchicine greatly increased axial length, equatorial diameter, eye weight, and myopic refractive error, while reducing corneal curvature. Colchicine caused DNA fragmentation in many GCs and some amacrine cells and photoreceptors, ultimately leading to the destruction...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Vision Research
DOI: 10.1016/S0042-6989(98)00178-3


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