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Analysis of NMDA-independent long-term potentiation induced at CA3-CA1 synapses in rat hippocampus in vitro

Stricker, Christian; Cowan, Anna; Field, A


1. Excitatory postsynaptic currents (EPSCs) were evoked at synapses formed by Schaffer collaterals/commissural (CA3) axons with CA1 pyramidal cells using the rat hippocampal slice preparation. Long-term potentiation (LTP) was induced at these synapses using a pairing protocol, with 50 μM D,L-APV present in the artificial cerebrospinal fluid (ACSF). 2. Quantal analysis of the amplitudes of the control and conditioned EPSCs showed that the enhancement of synaptic strength was due entirely to an...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Physiology
DOI: 10.1111/j.1469-7793.1999.00513.x


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