A malaria scavenger receptor-like protein essential for parasite development
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Claudianos, Charles; Dessens, Johannes T.; Trueman, Holly E.; Mendoza, Jacqui; Arai, Meiji; Butcher, Geoff A.; Crompton, Tessa; Sinden, Roberet E.
Description
Malaria parasites suffer severe losses in the mosquito as they cross the midgut, haemolymph and salivary gland tissues, in part caused by immune responses of the insect. The parasite compensates for these losses by multiplying during the oocyst stage to form the infectious sporozoites. Upon human infection, malaria parasites are again attenuated by sustained immune attack. Here, we report a single copy gene that is highly conserved amongst Plasmodium species that encodes a secreted protein...[Show more]
dc.contributor.author | Claudianos, Charles | |
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dc.contributor.author | Dessens, Johannes T. | |
dc.contributor.author | Trueman, Holly E. | |
dc.contributor.author | Mendoza, Jacqui | |
dc.contributor.author | Arai, Meiji | |
dc.contributor.author | Butcher, Geoff A. | |
dc.contributor.author | Crompton, Tessa | |
dc.contributor.author | Sinden, Roberet E. | |
dc.date.accessioned | 2015-12-13T23:40:13Z | |
dc.date.available | 2015-12-13T23:40:13Z | |
dc.identifier.issn | 0950-382X | |
dc.identifier.uri | http://hdl.handle.net/1885/94361 | |
dc.description.abstract | Malaria parasites suffer severe losses in the mosquito as they cross the midgut, haemolymph and salivary gland tissues, in part caused by immune responses of the insect. The parasite compensates for these losses by multiplying during the oocyst stage to form the infectious sporozoites. Upon human infection, malaria parasites are again attenuated by sustained immune attack. Here, we report a single copy gene that is highly conserved amongst Plasmodium species that encodes a secreted protein named PxSR. The predicted protein is composed of a unique combination of metazoan protein domains that have been previously associated with immune recognition/activation and lipid/protein adhesion interactions at the cell surface, namely: (i) scavenger receptor cysteine rich (SRCR); (ii) pentraxin (PTX); (iii) polycystine-1, lipoxygenase, alpha toxin (LH2/PLAT); (iv) Limulus clotting factor C, Coch-5b2 and Lgl1 (LCCL). In our assessment the PxSR molecule is completely novel in biology and is only found in Apicomplexa parasites. We show that PxSR is expressed in sporozoites of both human and rodent malaria species. Disruption of the PbSR gene in the rodent malaria parasite P. berghei results in parasites that form normal numbers of oocysts, but fail to produce any sporozoites. We suggest that, in addition to a role in sporogonic development, PxSR may have a multiplicity of functions. | |
dc.publisher | Blackwell Publishing Ltd | |
dc.source | Molecular Microbiology | |
dc.subject | Keywords: alpha toxin; blood clotting factor; cysteine; lipoxygenase; pentraxin; polycystin; protein; protein coch 5b2; protein lgl1; protein pxsr; scavenger receptor; unclassified drug; antigen recognition; Apicomplexa; article; cell surface; controlled study; gen | |
dc.title | A malaria scavenger receptor-like protein essential for parasite development | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 45 | |
dc.date.issued | 2002 | |
local.identifier.absfor | 060409 - Molecular Evolution | |
local.identifier.ariespublication | MigratedxPub23934 | |
local.type.status | Published Version | |
local.contributor.affiliation | Claudianos, Charles, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Dessens, Johannes T., Imperial College of Science Technology and Medicine | |
local.contributor.affiliation | Trueman, Holly E., Imperial College of Science Technology and Medicine | |
local.contributor.affiliation | Mendoza, Jacqui, Imperial College of Science Technology and Medicine | |
local.contributor.affiliation | Arai, Meiji, Imperial College of Science Technology and Medicine | |
local.contributor.affiliation | Butcher, Geoff A., Imperial College of Science Technology and Medicine | |
local.contributor.affiliation | Crompton, Tessa, Imperial College of Science Technology and Medicine | |
local.contributor.affiliation | Sinden, Roberet E., Imperial College of Science Technology and Medicine | |
local.bibliographicCitation.startpage | 1473 | |
local.bibliographicCitation.lastpage | 1484 | |
local.identifier.doi | 10.1046/j.1365-2958.2002.03118.x | |
dc.date.updated | 2015-12-12T09:28:20Z | |
local.identifier.scopusID | 2-s2.0-0036032145 | |
Collections | ANU Research Publications |
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