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A universal protein-protein interaction motif in the eubacterial DNA replication and repair systems

Dalrymple, Brian Paul; Kongsuwan, Kritaya; Wijffels, Gene; Dixon, Nicholas; Jennings, Peter Andrew


The interaction between DNA polymerases and sliding clamp proteins confers processivity in DNA synthesis. This interaction is critical for most DNA replication machines from viruses and prokaryotes to higher eukaryotes. The clamp proteins also participate in a variety of dynamic and competing protein-protein interactions. However, clamp-protein binding sequences have not so far been identified in the eubacteria. Here we show from three lines of evidence, bioinformatics, yeast two-hybrid...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.191384398


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