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Expression of the Ym2 Lectin-Binding Protein Is Dependent on Interleukin(IL)-4 and IL-13 Signal Transduction: Identification of a Novel Allergy-Associated Protein

Webb, Dianne; Mckenzie, Andrew N; Foster, Paul S


Asthma pathophysiology is intimately regulated by CD4+ Th2 lymphocytes and the cytokines interleukin (IL)-4 and IL-13. However, the mechanisms by which these cytokines promote disease have not been fully elucidated. In order to identify novel molecular mediators of allergy, a comparison was made of the bronchoalveolar lavage, which demonstrated that the Ym2 protein was abundantly up-regulated in the lung during the development of allergy. Low levels of the Ym1 isomer were also detected....[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M106223200


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