Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine cores
Date
2001
Authors
Wang, Gary
Chen, Yuanwei
Wang, Sheldon
Gentles, Andrew J
Sowin, Thomas
Kati, Warren
Muchmore, Steven
Giranda, Vincent
Stewart, Kent
Sham, Hing
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American Chemical Society
Abstract
The discovery of (±)-(2S,3R,4R)-2-(trifluoroacetamido)methyl-3-amino-1- (N′-ethyl-N′-isopropylcarbamyl)pyrrolidine-4-carboxylic acid (A-192558, 20e) as a potent inhibitor of influenza neuraminidase (NA) is described. Efficient syntheses of two core s
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Keywords
Keywords: 2 (trifluoroacetamido)methyl 3 amino 1 (n' ethyl n' isopropylcarbamyl)pyrrolidine 4 carboxylic acid; a 87380; pyrrolidine derivative; sialidase inhibitor; unclassified drug; zanamivir; article; conformational transition; drug design; drug structure; drug
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Source
Journal of Medicinal Chemistry
Type
Journal article
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2037-12-31
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