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Integron-sequestered dihydrofolate reductase: a recently redeployed enzyme

Alonso, Hernan; Gready, Jill


The introduction and wide use of antibacterial drugs has resulted in the emergence of resistant organisms. DfrB dihydrofolate reductase (DHFR) is a bacterial enzyme that is uniquely associated with mobile gene cassettes within integrons, and confers resistance to the drug trimethoprim. This enzyme has intrigued microbiologists since it was discovered more than thirty years ago because of its simple structure, enzymatic inefficiency and its virtual insensitivity to trimethoprim. Here, for the...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Trends in Microbiology
DOI: 10.1016/j.tim.2006.03.003


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