A pathological function for eotaxin and eosinphils in eosinphilic gastrontestinal inflammation
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Hogan, Simon P; Mishra, Anil; Brandt, Eric; Royalty, Michael; Pope, Samuel; Zimmermann, Nives; Foster, Paul S; Rothenberg, Marc E
Description
Although eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been established. Using a murine model of oral antigen-induced eosinophil-associated gastrointestinal disease, we report the pathological consequences of eosinophilic inflammation and the involvement of eotaxin and eosinophils. Exposure of mice to enteric-coated antigen promotes an extensive T helper 2-associated eosinophilic inflammatory response involving the esophagus, stomach,...[Show more]
Collections | ANU Research Publications |
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Date published: | 2001 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/92910 |
Source: | Nature Immunology |
DOI: | 10.1038/86365 |
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