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A pathological function for eotaxin and eosinphils in eosinphilic gastrontestinal inflammation

Hogan, Simon P; Mishra, Anil; Brandt, Eric; Royalty, Michael; Pope, Samuel; Zimmermann, Nives; Foster, Paul S; Rothenberg, Marc E

Description

Although eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been established. Using a murine model of oral antigen-induced eosinophil-associated gastrointestinal disease, we report the pathological consequences of eosinophilic inflammation and the involvement of eotaxin and eosinophils. Exposure of mice to enteric-coated antigen promotes an extensive T helper 2-associated eosinophilic inflammatory response involving the esophagus, stomach,...[Show more]

dc.contributor.authorHogan, Simon P
dc.contributor.authorMishra, Anil
dc.contributor.authorBrandt, Eric
dc.contributor.authorRoyalty, Michael
dc.contributor.authorPope, Samuel
dc.contributor.authorZimmermann, Nives
dc.contributor.authorFoster, Paul S
dc.contributor.authorRothenberg, Marc E
dc.date.accessioned2015-12-13T23:26:36Z
dc.date.available2015-12-13T23:26:36Z
dc.identifier.issn1529-2908
dc.identifier.urihttp://hdl.handle.net/1885/92910
dc.description.abstractAlthough eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been established. Using a murine model of oral antigen-induced eosinophil-associated gastrointestinal disease, we report the pathological consequences of eosinophilic inflammation and the involvement of eotaxin and eosinophils. Exposure of mice to enteric-coated antigen promotes an extensive T helper 2-associated eosinophilic inflammatory response involving the esophagus, stomach, small intestine and Peyer's patches as well as the development of gastric dysmotility, gastromegaly and cachexia. Electron microscopy shows eosinophils in proximity to damaged axons, which indicated that eosinophils were mediating a pathologic response. In addition, mice deficient in eotaxin have impaired eosinophil recruitment and are protected from gastromegaly and cachexia. These results establish a critical pathological function for eotaxin and eosinophils in gastrointestinal allergic hypersensitivity.
dc.publisherNature Publishing Group
dc.sourceNature Immunology
dc.subjectKeywords: antigen; beta chemokine; cytokine; eosinophil chemotactic factor; eotaxin; animal; article; electron microscopy; eosinophil; eosinophilia; gastrointestinal disease; genetics; human; immunology; inflammation; mouse; mouse mutant; oral drug administration;
dc.titleA pathological function for eotaxin and eosinphils in eosinphilic gastrontestinal inflammation
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume2
dc.date.issued2001
local.identifier.absfor110307 - Gastroenterology and Hepatology
local.identifier.ariespublicationMigratedxPub26162
local.type.statusPublished Version
local.contributor.affiliationHogan, Simon P, University of Cincinnati
local.contributor.affiliationMishra, Anil, Cincinnati Children's Hospital Medical Center
local.contributor.affiliationBrandt, Eric, University of Cincinnati
local.contributor.affiliationRoyalty, Michael, Cincinnati Children's Hospital Medical Center
local.contributor.affiliationPope, Samuel, Cincinnati Children's Hospital Medical Center
local.contributor.affiliationZimmermann, Nives, University of Cincinnati
local.contributor.affiliationFoster, Paul S, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRothenberg, Marc E, University of Cincinnati
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage353
local.bibliographicCitation.lastpage360
local.identifier.doi10.1038/86365
dc.date.updated2015-12-12T09:47:15Z
local.identifier.scopusID2-s2.0-0035318284
CollectionsANU Research Publications

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