A pathological function for eotaxin and eosinphils in eosinphilic gastrontestinal inflammation
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Hogan, Simon P; Mishra, Anil; Brandt, Eric; Royalty, Michael; Pope, Samuel; Zimmermann, Nives; Foster, Paul S; Rothenberg, Marc E
Description
Although eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been established. Using a murine model of oral antigen-induced eosinophil-associated gastrointestinal disease, we report the pathological consequences of eosinophilic inflammation and the involvement of eotaxin and eosinophils. Exposure of mice to enteric-coated antigen promotes an extensive T helper 2-associated eosinophilic inflammatory response involving the esophagus, stomach,...[Show more]
dc.contributor.author | Hogan, Simon P | |
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dc.contributor.author | Mishra, Anil | |
dc.contributor.author | Brandt, Eric | |
dc.contributor.author | Royalty, Michael | |
dc.contributor.author | Pope, Samuel | |
dc.contributor.author | Zimmermann, Nives | |
dc.contributor.author | Foster, Paul S | |
dc.contributor.author | Rothenberg, Marc E | |
dc.date.accessioned | 2015-12-13T23:26:36Z | |
dc.date.available | 2015-12-13T23:26:36Z | |
dc.identifier.issn | 1529-2908 | |
dc.identifier.uri | http://hdl.handle.net/1885/92910 | |
dc.description.abstract | Although eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been established. Using a murine model of oral antigen-induced eosinophil-associated gastrointestinal disease, we report the pathological consequences of eosinophilic inflammation and the involvement of eotaxin and eosinophils. Exposure of mice to enteric-coated antigen promotes an extensive T helper 2-associated eosinophilic inflammatory response involving the esophagus, stomach, small intestine and Peyer's patches as well as the development of gastric dysmotility, gastromegaly and cachexia. Electron microscopy shows eosinophils in proximity to damaged axons, which indicated that eosinophils were mediating a pathologic response. In addition, mice deficient in eotaxin have impaired eosinophil recruitment and are protected from gastromegaly and cachexia. These results establish a critical pathological function for eotaxin and eosinophils in gastrointestinal allergic hypersensitivity. | |
dc.publisher | Nature Publishing Group | |
dc.source | Nature Immunology | |
dc.subject | Keywords: antigen; beta chemokine; cytokine; eosinophil chemotactic factor; eotaxin; animal; article; electron microscopy; eosinophil; eosinophilia; gastrointestinal disease; genetics; human; immunology; inflammation; mouse; mouse mutant; oral drug administration; | |
dc.title | A pathological function for eotaxin and eosinphils in eosinphilic gastrontestinal inflammation | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 2 | |
dc.date.issued | 2001 | |
local.identifier.absfor | 110307 - Gastroenterology and Hepatology | |
local.identifier.ariespublication | MigratedxPub26162 | |
local.type.status | Published Version | |
local.contributor.affiliation | Hogan, Simon P, University of Cincinnati | |
local.contributor.affiliation | Mishra, Anil, Cincinnati Children's Hospital Medical Center | |
local.contributor.affiliation | Brandt, Eric, University of Cincinnati | |
local.contributor.affiliation | Royalty, Michael, Cincinnati Children's Hospital Medical Center | |
local.contributor.affiliation | Pope, Samuel, Cincinnati Children's Hospital Medical Center | |
local.contributor.affiliation | Zimmermann, Nives, University of Cincinnati | |
local.contributor.affiliation | Foster, Paul S, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Rothenberg, Marc E, University of Cincinnati | |
local.bibliographicCitation.issue | 4 | |
local.bibliographicCitation.startpage | 353 | |
local.bibliographicCitation.lastpage | 360 | |
local.identifier.doi | 10.1038/86365 | |
dc.date.updated | 2015-12-12T09:47:15Z | |
local.identifier.scopusID | 2-s2.0-0035318284 | |
Collections | ANU Research Publications |
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