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Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response

Simeonovic, Charmaine; Townsend, Michelle; Karupiah, Gunasegaran; Wilson, Judith; Zarb, Jodi; Mann, David; Young, I M


The rejection mechanisms for fetal proislet allografts and pig proislet xenografts in mice are characterized by different intragraft cytokine mRNA profiles and cellular responses. Allograft rejection is predominantly CD8 T- cell-dependent and is associated with a Th1-type cytokine pattern (i.e., IFN- γ, IL-2 but no IL-4 or IL-5 mRNA). In contrast, xenograft rejection is CD4 T-cell-dependent and is accompanied by a strong Th2-type response (i.e., enhanced expression of IL-4 and IL-5 mRNA) and by...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Cell Transplantation


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