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Alloreactive cytotoxic T-cell function, peptide nonspecific

Mullbacher, Arno; Lobigs, Mario; Kos, Ferdynand; Langman, Rod


The recognition requirements necessary for murine alloreactive cytotoxic T-cells to carry out their effector function has been investigated using target cells that express a unique class I major histocompatibility complex (MHC)-peptide pair. The human cell line T2 and the murine cell line RMA-S are defective in peptide transport components needed to effectively express stable MHC class I molecules at the cell surface. When T2 cells were infected with a vaccinia virus that encoded the K(d) gene...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Scandinavian Journal of Immunology
DOI: 10.1046/j.1365-3083.1999.00568.x


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