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Genetic vaccination strategies for enhanced cellular, humoral and mucosal immunity

Ramsay, Alistair; Kent, Stephen J; Strugnell, R; Suhrbier, A; Thomson, Scott; Ramshaw, Ian


In this article, we describe several novel genetic vaccination strategies designed to facilitate the development of different types of immune responses. These include: i) the consecutive use of DNA and fowlpoxvirus vectors in 'prime-boost' strategies which induce greatly enhanced and sustained levels of both cell-mediated immunity and humoral immunity, including mucosal responses; ii) the co-expression of genes encoding cytokines and cell-surface receptors, and the use of immunogenic carrier...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Immunological Reviews
DOI: 10.1111/j.1600-065X.1999.tb01341.x


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