Interferon-inducible chemokines and immunity to poxvirus infections
Date
2000
Authors
Mahalingam, Surendran
Foster, Paul S
Lobigs, Mario
Karupiah, Gunasegaran
Journal Title
Journal ISSN
Volume Title
Publisher
Annual Reviews Inc
Abstract
The biological roles of two interferon-inducible chemokines, monokine induced by gamma interferon (Mig) and cytokine responsive gene (Crg-2), in the immune response against vaccinia virus (VV) and ectromelia virus (EV) infections are discussed. To investigate their antiviral effects in vivo, the expression profiles of these chemokines during the course of VV or EV infections were first established. Mig and Crg-2 were induced in multiple organs at high levels early after infection with VV. Both chemokines were rapidly induced in popliteal lymph nodes of C57BL/6 mice but not in BALB/c mice following infection with EV. Secondly, recombinant vaccinia viruses (rVV) encoding Mig or Crg-2 were constructed to investigate the immunobiology of infection in athymic, nude and euthymic, normal mice. Finally, the EV model in combination with recombinant Mig and Crg-2 proteins was used to test their effects on viral replication and immune responses in vivo. The results of these investigations demonstrate that the mechanisms of Mig- and Crg-2-induced viral clearance involve natural killer cells and interferons.
Description
Keywords
Keywords: chemokine; gamma interferon; interferon; monokine; virus protein; animal experiment; animal model; controlled study; cytokine responsive element; Ectromelia virus; female; gene induction; immune response; mouse; natural killer cell; nonhuman; Poxvirus; pr
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Source
Annual Review of Immunology
Type
Journal article