Skip navigation
Skip navigation

Distinct importin recognition properties of histones and chromatin assembly factors.

Johnson-Saliba, Melanie; Siddon, Nicole; Clarkson, M J; Tremethick, David; Jans, David A

Description

Synthesis of the protein components of nuclear chromatin occurs in the cytoplasm, necessitating specific import into the nucleus. Here, we report the binding affinities of the nuclear localisation sequence (NLS)-binding importin subunits for a range of histones and chromatin assembly factors. The results suggest that import of histones to the nucleus may be mediated predominantly by importin β1, whereas the import of the other components probably relies on the conventional α/β1 import pathway....[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/89138
Source: FEBS Letters
DOI: 10.1016/S0014-5793(00)01142-X

Download

File Description SizeFormat Image
01_Johnson-Saliba_Distinct_importin_recognition_2000.pdf226.07 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator