The Three-Dimensional Structure of the 4:1 Mithramycin:d(ACCCGGGT)2 Complex: Evidence for an Interaction Between the E Saccharides
Date
2000
Authors
Keniry, Max
Owen, Elisabeth
Shafer, Richard
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John Wiley & Sons Inc
Abstract
Mithramycin and chromomycin, two antitumor drugs, each having an identical aglycone and nearly' identical disaccharide and trisaccharide side chains, have differing binding properties to a small oligonucleotide, d(ACCCGGGT)2 (M. A. Keniry et al., Journal
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Keywords
Keywords: Acetylation; Antibiotics; Chemical bonds; Conformations; Dimers; Mathematical models; Molecular dynamics; Molecular structure; Nuclear magnetic resonance spectroscopy; Polysaccharides; Stereochemistry; Mithramycin; Oligonucleotides; Nucleic acids; chromom Drug-DNA; Mithramycin; Oligonucleotide; Two-dimensional nmr
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Source
Biopolymers
Type
Journal article
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2037-12-31
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