Skeletal muscle ryanodine receptor channels are activated by the fungal metabolite, gliotoxin
Date
2000
Authors
Green, Daniel
Pace, Suzy M
Hurne, Alanna
Waring, Paul
Hart, James
Dulhunty, Angela
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
Interactions between the reactive disulfide fungal metabolite, gliotoxin (GTX), and rabbit skeletal ryanodine receptor (RyR) calcium release channels have been examined. RyRs in terminal cisternae vesicles formed a covalent complex with 100 μM35S-GTX, wh
Description
Keywords
Keywords: dithiothreitol; gliotoxin; ryanodine receptor; animal cell; article; calcium transport; lipid bilayer; nonhuman; oxidation; rabbit; sarcoplasmic reticulum; Animals; Calcium; Dithiothreitol; Gliotoxin; Molecular Structure; Muscle, Skeletal; Rabbits; Ryanod Calcium regulation; Gliotoxin; Ryanodine receptors
Citation
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Source
Journal of Membrane Biology
Type
Journal article