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Pgh modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

Reed, M; Saliba, Kevin; Caruana, S R; Kirk, Kiaran; Cowman, A


Throughout the latter half of this century, the development and spread of resistance to most front-line antimalarial compounds used in the prevention and treatment of the most severe form of human malaria has given cause for grave clinical concern. Polymorphisms in pfmdr1, the gene encoding the P-glycoprotein homologue 1 (Pgh1) protein of Plasmodium falciparum, have been linked to chloroquine resistance; Pgh1 has also been implicated in resistance to mefloquine and halofantrine. However,...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Nature
DOI: 10.1038/35002615


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