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Inhibition of Inflammation and Remodeling by Roflumilast and Dexamethasone in Murine Chronic Asthma

Kumar, Rakesh K; Herbert, John; Thomas, Paul S; Wollin, Lutz; Beume, Rolf; Yang, Ming; Webb, Dianne; Foster, Paul S


Phosphodiesterase (PDE) inhibitors have potential as alternatives or adjuncts to glucocorticoid therapy in asthma. We compared roflumilast (a selective PDE4 inhibitor) with pentoxifylline (a nonselective inhibitor) and dexamethasone in ameliorating the lesions of chronic asthma in a mouse model. BALB/c mice sensitized to ovalbumin were chronically challenged with aerosolized antigen for 6 weeks. During weeks 5 and 6, groups of animals were treated with roflumilast or dexamethasone by daily...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Pharmacology and Experimental Therapeutics
DOI: 10.1124/jpet.103.053819


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